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PUBLICATIONS

Journal Publications

  • McArthur, K, Kay, A, Mosier, J, Grant, J, Stewart, JA, Simpson, CL. “Manipulating the Plasticity of Smooth Muscle Cells to Regulate Vascular Calcification.” AIMS Cell and Tissue Engineering. 1, 3 (2017): 165-179.

  • Kay, A, Simpson, CL, and Stewart, JA Jr. “The Role of AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification.” Journal of Diabetes Research. 2016 (2016) Article ID 6809703, 8 pages.

  • Smith, P, Kay, A, Dunaway, L, and Simpson, CL. “Injectable Biomaterials for Cell, Gene and Protein Therapy.” Materials Technology: Advanced Biomaterials. 30, Supp 5 (2015):264-272.

  • Vasquez, E.S.; Cunningham, J.L.; McMahan, J.B.; Simpson, C.L. and Walters, K.B. “Fetuin-A Adsorption, Stabilization, and Solubilization of Amorphous Calcium Carbonate Nanoparticles,” Journal of Materials Chemistry B. 3 (2015): 6411-6419.

  • Vasquez, E.S.; Cunningham, J.L.; McMahan, J.B.; Simpson, C.L. and Walters, K.B. “Front Cover” Journal of Materials Chemistry B. 3 (2015): 6393-6394.

  • Grant JN, Simpson CL. “Osteoclast-Mediated Demineralizing of Medial Vascular Calcification.” Journal of the Mississippi Academy of Sciences. 59.1 (2014): 343-346.

  • Cunningham JL, Vasquez ES, Walters KB, Simpson CL. “Targeted Therapy to Treat Cardiovascular Calcification in ESRD Patients.” Journal of the Mississippi Academy of Sciences. 59.1 (2014): 335-338.

  • Bennett K, Simpson CL. “Treatment of Vascular Calcification by Elastin-Targeted Nanoparticles,” Journal of the Mississippi Academy of Sciences. 59.1 (2014): 170-173.

  • Sonnet, C, Simpson, CL, Olabisi, RM, Sullivan, K, Hipp, J, Lazard, Z, Gugala, Z, Gannon, F, Stice, S, Peroni, J, Weh, M, Sevick, E, Heggeness, M, Davis, AR, West, JL, Olmsted-Davis, EA. Cell Based Gene Therapy for Fracture Healing in a Rat Femoral Critical Size Defect. Journal of Orthopedic Research. 31 (2013) 1597-1604.

  • Lu, Y, Darne, C, Tan, I, Simpson, CL, Zhu, B, Hall, M, Lazard, Z, Davis, AR, Sevick-Muraca, E, Olmsted-Davia, EA. Far-red Fluorescence Gene Reporter Tomography for Determination of Placement and Viability of Cell-Based Gene Therapies. Journal of Optics Express. 21 (2013) 24129-24138.

  • Simpson, CL, Lindley S, Eisenburg C, Basalyga D, Starcher B, Simionescu D, Vyavahare N., Towards Cell Therapy for Vascular Calcification:  Osteoclast-Mediated Demineralization of Calcified Elastin. Journal of Cardiovascular Pathology, Cardiovascular Pathology, 16 (2007) 29-37.

Invited Talks

  • Simpson, CL. “You’re on the Right Track.” Undergraduate Summer Research Symposium. Mississippi State University, Mississippi State, MS. August 2018.

  • Simpson, CL. “Assessment of Community-Engaged Courses.” Community-Engaged Learning Faculty Fellows Course. Mississippi State University, Mississippi State, MS. May 2018.

  • Simpson, CL. “Protein Therapy to Arrest the Phenotypic Switching of Smooth Muscle Cells in Vascular Calcification.” Darwin Week. Mississippi State University, Mississippi State, MS. February 2018.

  • Simpson, CL. “Cell and Protein Therapy to Treat Vascular Calcification.” Cardiovascular and Renal Research Center. University of Mississippi Medical Center, Jackson, MS. May 2017.

  • Simpson, CL. “Protein Therapy to Arrest the Phenotypic Switching of Smooth Muscle Cells in Vascular Calcification.” 2016 Southeast Symposium on Contemporary Engineering Topics. Jackson, MS. August 2016.

  • Simpson, CL. “Understanding and Treating Vascular Calcification.” Department of Medical Physiology. Texas A&M Health Science Center College of Medicine, College Statation, TX. December 2015.

  • Simpson, CL. “Understanding and Treating Vascular Mineralization.” Geosciences Brown Bag Seminar. Mississippi State University, Mississippi State, MS. November 2015.

  • Cunningham J, McMahan J, Simpson CL. “Protein Therapy for the Treatment of Vascular Calcification in Patients with Chronic Kidney Disease.” Network of Minority Health Research Investigators South Regional Workshop. November 2015.

  • Simpson, CL. “Targeted Therapies for Vascular Calcification.” Call Me Doctor Seminar Series. Clemson University, Clemson, SC. May 2015.

  • Simpson, CL. “Targeted Therapies for Cardiovascular Disease.” Department of Biological Sciences. Mississippi State University, Mississippi State, MS. October 2015. Simpson, CL. Cell and Gene Therapy for Calcified Tissues. Department of Agricultural & Biological Engineering. Mississippi State University. Starkville, MS. Apr 2012.

  • Simpson, CL. Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin-Specific Vascular Calcification.  Department of Cell and Gene Therapy. Baylor College of Medicine. Houston, TX. June 2010.

  • Simpson, CL. Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin-Specific Vascular Calcification. Department of Bioengineering. Rice University. Houston, TX. Dec 2009.

  • Simpson, CL. Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin-Specific Vascular Calcification. The Wallace H. Coulter Department of Biomedical Engineering. Atlanta, GA. Nov 2009.

Book Chapter

  • Mosier J, Nguyen N, Parker K, and Simpson CL. "Calcification of Biomaterials and Diseased States". Biomaterials - Physics and Chemistry – New Edition. Eds. Pignatello, R and Musumeci, T. London, United Kingdom: InTechOpen.(2018) 37-60.

  • McMahan, J, Hybart, R, Simpson, CL. “Cardiovascular 3D Test Systems.” Engineering 3D Test Systems. Eds.  Burg, T, Dreau, D, Burg, K. Boca Raton, FL: CRC Press, Submitted Feb 2016.

Proceedings and Abstracts

  • Travis, C. Roach, C., Simpson, C. L., "Examining the Signaling Pathways Connecting Endothelial-Mesenchymal Transition (EndMT) and Smooth Muscle Cells in Vascular Calcification," Vascular Discovery: From Genes to Medicine Scientific Sessions, Boston, MA. 14 May 2019. Poster Presentation.

  • Travis, C. Roach, C., Simpson, C. L., "Examining the Signaling Pathways Connecting Endothelial-Mesenchymal Transition (EndMT) and Smooth Muscle Cells in Vascular Calcification," Society for Biomaterials, Seattle, WA. 3 April 2019. Poster Presentation.

  • Mosier, J., Hybart, R., Mullins, V., Simpson, C.L., “Using an In Vitro Uremic Model to Determine the Effects of Fetuin-A on Vascular Calcification,” Biomedical Engineering Society Annual Meeting. Atlanta, GA. 19 October 2018. Poster Presentation.

  • Rexrode, L., McArthur, K., Kay, A., Stewart, J.A., Simpson, C.L., “Sclerostin as a Potential Therapy to Treat Vascular Calcification,” Biomedical Engineering Society Annual Meeting. Atlanta, GA. 19 October 2018. Poster Presentation.

  • Simpson, C.L., Rexrode, L., McArthur, K., Kay, A., Stewart, J.A., “Sclerostin as a Potential Therapy to Treat Vascular Calcification,” International Society for Applied Cardiovascular Biology, Bordeaux, France. 17 September 2018. Poster Presentation.

  • Mosier, J., Hybart, R., Kay, A., Stewart, J. A., Simpson, C. L., "The Therapeutic Effect of Fetuin-A on the Calcified State of Smooth Muscle Cells," Society for Biomaterials, Atlanta, GA. 13 April 18. Oral Presentation.

  • Mullins, V., Simpson, C. L., "Alginate Hydrogels as an Osteoclast Delivery System," Society forBiomaterials, Atlanta, GA. 12 April 18. Poster Presentation.

  • Nguyen, N., Simpson, C. L., "Examining Cellular Mechanics in Vascular Calcification," Society for Biomaterials, Atlanta, GA. 12 April 18. Poster Presentation.

  • Parker, K., McArthur, K., Kay, A., Stewart, J. A., Simpson, C. L., "Protein-Based Inhibitor Used to Regulate the Phenotypic Switch of Smooth Muscle Cells," Society for Biomaterials, Atlanta, GA. 12 April 12 18. Poster Presentation.

  • Mosier, J., Hybart, R., Kay, A., Stewart, J. A., Simpson, C. L., "Novel Protein Therapy to Reverse and Inhibit Calcification of Vascular Smooth Muscle Cells,", 34th Southern Biomedical Engineering Conference, Charlotte, NC. 9 March 18. Oral Presentation.

  • Rexrode, L., Parker, K., McArthur, K., Mosier, J., Kay, A., Stewart, J. A., Simpson, C. L., "Protein-Based Inhibitor Used to Regulate the Phenotypic Switch of Smooth Muscle Cells," 34th Southern Biomedical Engineering Conference, Charlotte, NC. 9 March 9 18. Oral Presentation.

  • Mullins, V., Simpson, C. L., "Alginate Hydrogels as an Osteoclast Delivery System," Biomaterials Day, Memphis, TN. 2 March 2 18. Poster Presentation.

  • Tyson, J. H., Simpson, C. L., "Understanding Cardiovascular Calcification through Mathematic Modeling of the Canonical WNT Signaling Pathway," Biomaterials Day, Memphis, TN. 2 March 18. Oral Presentation.

  • Mosier, J., Hybart, R., Kay, A., Stewart, J. A., Simpson, C. L., 83rd Annual Mississippi Academy of Sciences Meeting, "The Use of Fetuin-A to Attenuate Calcification of Smooth Muscle Cells," Mississippi Academy of Sciences, Hattiesburg, MS. 23 February 18. Oral Presentation.

  • Coats, L, Fisher, M, Scott-Bracey, P, and Simpson, CL. “Preparing Black Female Faculty for Prominence, Power, and Presence in the Academy.” Mid-South Educational Research Association Annual Meeting. 8 November 17. Oral Presentation.

  • Mosier, J, Hybart, R, Kay, A, Stewart, JA, and Simpson, CL. “Effect of Fetuin-A Protein Therapy for Calcification of Vascular Smooth Muscle Cells in vascular calcification”. 2017 Biomedical Engineering Society Annual Meeting. Phoenix, AZ. 11 October 17. Poster Presentation.

  • McArthur, K, Kay, A, Stewart, JA, and Simpson, CL. “Sclerostin Supplementation as an Effective Therapy in Vascular Calcification.” 2017 Biomedical Engineering Society Annual Meeting. Phoenix, AZ. 11 October 17. Poster Presentation.

  • Coats, L, Fisher, M, Simpson, CL, and Scott-Bracey, P. “Preparing Black Female Faculty for Prominence, Power, and Presence in the Academy.” 10th Annual College of Education Faculty and Student Research Forum. 21 April 17. Oral Presentation.

  • Simpson, CL. “Improving Scientific Communication of Undergraduates through Peer Evaluation.” 2017 Society for Biomaterials Annual Meeting. Minneapolis, MN. 4 April 17. Poster Presentation.

  • Hybart, R, Kay, A, Stewart, JA, and Simpson, CL. “Fetuin-A supplementation as an Effective Therapy in Regulating Phenotypic Differentiation of Smooth Muscle Cells in Vascular Calcification”. 2017 Society for Biomaterials Annual Meeting. Minneapolis, MN. 4 April 17. Poster Presentation.

  • McArthur, K, Kay, A, Stewart, JA, and Simpson, CL. “Phenotypic Switch of Vascular Smooth Muscle Cells in Vascular Calcification”. 33rd Annual Southern Biomedical Engineering Conference. Gulfport, MS. 17 March 17. Poster Presentation.

  • Parker, P and Simpson, CL. “Fluorescent Imaging of Calcified Vascular Smooth Muscle Cells.” 82nd Annual Mississippi Academy of Sciences Annual Meeting. Hattiesburg, MS. 23 February 17. Poster Presentation.

  • McMahan J, Kay A, Stewart JA, Simpson, CL. “Fetuin-A Supplementation as an Effective Therapy in Regulating Phenotypic Differentiation of Smooth Muscle Cells in Vascular Calcification.” 2016 Biomedical Engineering Society Annual Meeting. Minneapolis, MN. 6 October 16. Poster Presentation.

  • Alexander M, Simpson CL. “Three Dimensional Arterial Model to Simulate and Characterize Vascular Calcification In Vitro.” Mississippi Academy of Sciences Annual Meeting. Hattiesburg, MS. 18 February 2016. Poster Presentation.

  • Kay A, Grant J, Simpson CL. “Genetic Switching of Vascular Smooth Muscle Cells.” 2015 Biomedical Engineering Society Annual Meeting. Tampa, FL. 7 October 15. Poster Presentation.

  • Adeyemo P, Grant JN, Simpson CL. “Imaging of Calcified Vascular Smooth Muscle Cells.” Shackoul’s Honors College Summer Undergraduate Research Symposium 2015. Mississippi State University, Mississippi State, MS. 30 July 2015. Poster Presentation. Outstanding Research Award for 1st place in Biological Sciences and Engineering.

  • Kay A, Grant J, Simpson CL. “Genetic Switching of Vascular Smooth Muscle Cells.” 31st Annual Southern Biomedical Engineering Conference. New Orleans, LA. 30 April 15. Oral Presentation.

  • Kay A, Grant J, Simpson CL. “Genetic Switching of Vascular Smooth Muscle Cells.” Shackoul’s Honors College Spring Undergraduate Research Symposium 2015. Mississippi State University, Mississippi State, MS. 23 April 15. Oral Presentation.

  • McMahan, J.; Cunningham, J. L.; Vasquez, E.S.; Walters, K.B.; Simpson, C.L., “Fetuin-A Therapy: A New Approach for the Treatment of Vascular Calcification” Society for Biomaterials 2015 Annual Conference. Charlotte, NC. 15 April 15. Oral Presentation.

  • Cunningham, J. L.; Vasquez, E.S.; Walters, K.B.; Simpson, C.L., “Human Fetuin-A Treatment for Demineralization of Arteriosclerosis” Society for Biomaterials 2015 Annual Conference. Charlotte, NC, April 1518, 2015. Oral Presentation.

  • Grant JN, Simpson CL. “Toward Cell Therapy: A Model for Vascular Calcification.” 12th Annual Graduate Student Research Symposium. Mississippi State University, Mississippi State, MS. 21 Mar 2015.

  • Bennett K, Simpson CL. “Treatment of Vascular Calcification with Elastin-Targeted Nanoparticles.” 2014 Biomedical Engineering Society Annual Meeting. Henry B. Gonzalez Convention Center, San Antonio, TX. 25 Oct 2014. Poster presentation.

  • McMahan J, Cunningham JL, Vasquez ES, Walters KB, Simpson CL. “Characterization of the Fetuin- Calcium Binding Interaction.” Shackoul’s Honor College Summer Undergraduate Research Symposium 2014. Mississippi State University, Mississippi State, MS. 31 July 2014. Talk. Outstanding Research Award for 3rd place in Biological Sciences and Engineering.

  • McGuire KA, Grant JN, Simpson CL. “3D Model for Vascular Calcification.” Bagley College of Engineering Undergraduate Research Poster Competition. Mississippi State University, Mississippi State, MS. 23 Apr 2014. Poster Presentation.

  • Grant JN, Simpson CL. “Osteoclast-Mediated Demineralizing of Medial Vascular Calcification.” 30th Annual Southern Biomedical Engineering Conference. Courtyard by Marriott Beachfront, Gulfport, MS. 12 Apr 2014. Oral Presentation.

  • Cunningham JL, Vasquez ES, Walters KB, Simpson CL. “Targeted Therapy to Treat Cardiovascular Calcification in ESRD Patients.” 30th Annual Southern Biomedical Engineering Conference. Courtyard by Marriott Beachfront, Gulfport, MS. 12 Apr. 2014. Oral Presentation.

  • Bennett K, Simpson CL. “Treatment of Vascular Calcification by Elastin-Targeted Nanoparticles.” 30th Southern Biomedical Engineering Conference. Courtyard by Marriot Beachfront, Gulfport, MS. 11 Apr 2014. Oral presentation.

  • McGuire KA, Grant JN, Simpson CL. “3D Model for Vascular Calcification.” Shackoul’s Honors College Spring Undergraduate Research Symposium 2014. Mississippi State University, Mississippi State, MS. 3 April 2014. Poster Presentation.

  • Cunningham JL, Vasquez ES, Walters KB, Simpson CL. “Targeted Therapy to Treat Cardiovascular Calcification in ESRD Patients.” 12th Annual Graduate Student Research Symposium. Mississippi State University, Mississippi State, MS. 22 Mar. 2014. Poster presentation. Outstanding Research Award for 1st place in Life and Biomedical Sciences and Engineering.

  • Bennett K, Simpson CL. “Treatment of Vascular Calcification with Elastin-Targeted Nanoparticles.” 12th Annual Graduate Student Research Symposium. Mississippi State University, Mississippi State, MS. 22 Mar 2014. Oral presentation.

  • Simpson, CL, Lazard, Z, Olabisi, RM, Davis, AR, Olmsted-Davis, EA, West, JL. Spinal Fusion through a NonInvasive Injectable Cell-Based Gene Therapy Method. BioMedical Engineering Society. Atlanta, GA. Oct, 2012. Oral Presentation.

  • Lu, Y, Simpson, CL, Lazard, Z, Olmsted-Davis, EA, Davis, AR, West, JL, Tan, I, Darne, C, Hall, MA, Robinson, H, Sevick, E. Multimodal Tomography for Localization of BMP2 Transduced Cells for Spine Fusion. World Molecular Imaging Conference. Dublin, Ireland. Sept, 2012. Poster Presentation.

  • Simpson, CL, Lazard, Z, Olabisi, RM, Davis, AR, Olmsted-Davis, EA, West, JL. A Non-Invasive Injectable CellBased Gene Therapy for Spine Fusion. Southern BioMedical Engineering Society. Houston, TX. May, 2012. Oral Presentation.

  • Simpson, CL, Lazard, Z, Olabisi, RM, Davis, AR, Olmsted-Davis, EA, West, JL. A Non-Invasive Injectable CellBased Gene Therapy for Spine Fusion. TERMIS-NA. Houston, TX. Dec, 2011. Oral Presentation.

  • Simpson, CL, Sonnet, C, Olabisi, RM, Sullivan, K, Davis, AR, Davis, EM, West, JL. Critical Size Defect Repair through a Gene Therapy Approach. BioMedical Engineering Society. Hartford, CT. Oct, 2011. Oral Presentation.

  • Sonnet, C, Simpson, CL, Olabisi, RM, Sullivan, K, Hipp, J, Lazard, Z, Gugala, Z, Gannon, F, Stice, S, Peroni, J, Weh, M, Sevick, E, Heggeness, M, Davis, AR, West, JL, Olmsted-Davis, E. Cell Based Gene Therapy for Fracture Healing in a Rat Femoral Critical Size Defect. American Society for Bone and Mineral Research. San Diego, CA. Sept, 2011.

  • Olabisi, RM, Simpson, CL, Sonnet, C, Lazard, Z, Sullivan, K, Davis, AR, Davis, EA, West, JL. Robust Femoral Critical Size Defect Repair via Injection of Hydrogel Microencapsulated Transduced Allogeneic Cells. Gordon Research Conference: Biomaterials & Tissue Engineering, Holderness, NH, 31 July, 2011.

  • Simpson, CL, Sonnet, C, Sullivan, K, Olabisi, RM, Davis, AR, Olmsted-Davis, EA, West, JL. Critical Size Defect Repair Through a Gene Therapy Approach. Gordon Research Conference: Tissue Repair and Regeneration. New London, NH. June, 2011.

  • Simpson, CL, Sonnet, C, Sullivan, K, Olabisi, RM, Davis, AR, Olmsted-Davis, EA, West, JL. Critical Size Defect Repair Through a Gene Therapy Approach. Society for Biomaterials: Biomaterials Day. College Station, TX. May, 2011.

  • Olabisi, RM, Sonnet, C, Simpson, CL, Lazard, Z, Sullivan, K, Davis, AR, West, JL, Olmsted-Davis, EA. Hydrogel Microencapsulation Permits Critical Size Defect Repair via Gene Therapy. Society for Biomaterials Annual Meeting. Orlando, FL. April, 2011.

  • Olabisi, RM, Sonnet, C, Lazard, Z, Simpson, CL, Davis, AR, Olmsted-Davis, EA, West, JL. Critical Size Defect Repair through a Single Injection. Orthopedic Research Society Annual Meeting. Los Angeles, CA. January, 2011.

  • Rajgariah, A, Olabasi, RM, Simpson, CL, West, JL. Determining the Number of Cells Microencapsulated within PEGDA Hydrogel Microspheres. Biomedical Engineering Society Annual Meeting. Austin, TX. October, 2010

  • Simpson, CL, Cheluvaraju, C, Vyavahare, N. Site-Specific Osteoclast-Mediated Cell Therapy for Vascular Calcification. Society for Biomaterials Annual Meeting. Seattle, WA. April 2010

  • Chelevaraju, C, Simpson, L, Vyavahare, N. Cathepsins are Upregulated in Vascular Calcification. Society for Biomaterials Annual Meeting. Seattle, WA. April 2010

  • Simpson, CL, Vyavahare, N. Cell Therapy as a Novel Treatment for Vascular Calcification. South Carolina Science, Technology and Health Conference and South Carolina Academy of Science Annual Meeting. Columbia, SC. April 2009

  • Simpson, CL, Yuan Y, Simionescu D, Bateman T, Vyavahare N. Osteoclast Precursors from Bone Marrow Resorb Elastin Calcification.  Biomedical Engineering Society Annual Meeting, Chicago, IL.  October 2006

  • Weinbrenner, DR, Burdick, JA, Simpson, CL, Lickfield, G, Laberge, M.  Dextran Hydrogel Used as a Phospholipid Delivery System for Viscosupplementation, Society for Biomaterials Annual Meeting, Pittsburgh, PA. April 2006

  • Simpson, CL, Lindley S, Basalyga D, Simionescu D, Vyavahare N. Osteoclast-Mediated Demineralization of Calcified Elastin.  Society for Biomaterials Annual Meeting, Memphis, TN. April 2005

  • Simpson, CL, Lindley S, Simionescu D, Vyavahare N. International Society for Applied Cardiovascular Biology Biennial Meeting, Savannah, GA. March 2004

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